May 26, 2022 · The main treatment of pulmonary Langerhans cell histiocytosis is smoking cessation, which leads to symptom resolution in up to one third of patients. Empiric use of corticosteroids and cytotoxic drugs is common practice even though their effectiveness is …

The pathogenesis, clinical presentation, diagnosis, and treatment of PLCH will be reviewed here. A general review of Langerhans cell histiocytosis, including the more common, extrapulmonary …

Jun 6, 2024 · Langerhans Cell Histiocytosis (LCH) treatment depends on where it is found in the body and whether the LCH is low or high risk. Treatment can include chemotherapy, surgery, radiation therapy, photodynamic therapy, immunotherapy, and targeted therapy. Learn more in this expert-reviewed summary.

Jan 6, 2025 · Langerhans cell histiocytosis (LCH) treatment may include observation alone, surgery, radiation therapy, or oral, topical, and intravenous medication. Treatment depends on the site and extent of disease.

Pulmonary Langerhans’ cell histiocytosis (PLCH) is an unusual cystic lung disease that is also characterized by extrapulmonary manifestations. The current review discusses the presenting features and relevant diagnostic testing and treatment options for PLCH in the context of a …

Jul 2, 2015 · Due to persistence despite topical therapy for 2 months, a skin biopsy is diagnostic of Langerhans cell (LC) histiocytosis (LCH). Evaluation for other sites of disease reveals he has “skin-only” LCH.

Apr 28, 2022 · Most adults with unifocal disease may be cured by local therapies, while the first-line treatment for single-system pulmonary LCH remains smoking cessation. Among patients not amenable or unresponsive to these treatments and/or have multifocal and multisystem disease, systemic treatments are recommended.

The best treatment for high-risk LCH is usually chemotherapy (chemo). It may last about a year. Chemotherapy uses powerful medicines to kill cells or stop them from growing (dividing) and making more cells. Newer treatments that target cells with mutations in the BRAF gene or other related genes are currently being investigated.

Apr 28, 2022 · The recommendations favor the use of 18F-Fluorodeoxyglucose positron emission tomography-based imaging for staging and response assessment in the majority of cases. Most adults with unifocal disease may be cured by local therapies, while the first-line treatment for single-system pulmonary LCH remains smoking cessation.

Lung transplantation is usually curative when combined with smoking cessation. Five-year survival is about 74%. Patients are at increased risk of cancer.