Looking between cells: Light microscopy probe provides unprecedented view of extracellular matrix
Before arriving at Janelia three years ago, Postdoctoral Scientist Antonio Fiore was designing and building optical ...
Nature12y
Cell Adhesion and Cell Communication
as well as between these cells and the extracellular matrix. These signaling pathways are critical to maintaining the state of equilibrium known as homeostasis within a tissue. For example ...
Innovative Microscopy Tool Provides a New Way To See What Lies Between Cells
Scientists have developed Rhobo6, a light microscopy probe that reveals extracellular matrix structures in live tissues, advancing biological research and disease diagnostics. Rhobo6 is a light ...
BioWorld10d
Insights into extracellular matrix are metastasis map
New research has uncovered a complex interplay between extracellular matrix (ECM) structure and the transcriptional responses ...
Tweaking cell binding can improve ultrasound cancer treatment: Study
BENGALURU: Cells and spacing between them plays a crucial role for a healthy body. A team of researchers from the Indian ...
eLife15d
Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche
Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...
eLife13d
Bridging the Gap in Cancer Cell Behavior Against Matrix Stiffening: Insights from a Trizonal Model
Laboratory for Research on the Structure of Matter (LRSM), University of Pennsylvania, Philadelphia, United States ...
Phys.org14d
Looking between cells: Light microscopy probe provides unprecedented view of extracellular matrix
So far, Fiore's new direction is paying off. The extracellular matrix supports and gives structure to our cells and tissues: It provides a scaffold for cells to grow in, dictates the mechanical ...