Head coach Kyle Shanahan sits down with Greg Papa on "49ers Game Plan" to discuss the development of rookie Isaac Guerendo ...

Kyle Shanahan explained to NBC Sports Bay Area’s Greg Papa on “49ers Game Plan" why San Francisco's offense won’t change ...

Samuel (calf) has been ruled out for Sunday's game against the Rams, Matt Barrows of The Athletic reports.

Brock Purdy plays much better with Deebo Samuel than without him. That's a fact. This Sunday, Purdy and the 49ers will have ...

The 49ers revealed their status reports Friday for their injured players ahead of Sunday’s visit to the Los Angeles Rams.

With Christian McCaffrey already on the injured reserve, Deebo Samuel has been ruled out due to injury for Week 3 in Los ...

Sunday’s NFC West showdown between the San Francisco 49ers and Los Angeles Rams could be an ugly affair, as both teams are ...

The 49ers revealed their status reports Friday for their injured players ahead of Sunday’s visit to the Los Angeles Rams.

The Minnesota Vikings will be without wide receiver Jordan Addison on Sunday when they host the San Francisco 49ers at U.S.

The San Francisco 49ers will likely be without All-Pro tight end George Kittle for Sunday's game against the Los Angeles Rams ...

Week 3 matchup vs. Rams with key injuries to McCaffrey, Samuel, and Kittle, testing their depth in this crucial NFC West ...

The San Francisco 49ers did not get good news on tight end George Kittle, who remains doubtful for the Rams game with ...