BMJ1y
Monocyte alterations in rheumatoid arthritis are dominated by preterm release from bone marrow and prominent triggering in the joint
In detail, RA transcriptomes of BM and blood monocytes overlapped with signatures of precursors in myelopoietic differentiation, indicating a so-called ‘left-shift’. Accelerated monocytopoiesis in ...
BMJ28d
Non-classical monocytes as mediators of tissue destruction in arthritis
Objectives Bone destruction in rheumatoid arthritis is mediated by osteoclasts (OC), which are derived from precursor cells of the myeloid lineage. The role of the two monocyte subsets, classical ...
thorax.bmj8y
S50 Monocytes from IPF patients show pre-conditioned pro-repair features
We investigate how monocytes (precursors of monocyte-derived lung macrophages) might contribute to fibrogenesis in IPF. Methods 35 IPF patients (25 sampled while stable and 10 with AE-IPF) diagnosed ...
gut.bmj1mon
Expression of interleukin 1β and interleukin 1β converting enzyme by intestinal macrophages in health and inflammatory bowel disease
Background—In the lipopolysaccharide (LPS) stimulated peripheral blood monocyte, the precursor form of interleukin 1β (IL-1β, 31 kD) is processed by IL-1β converting enzyme (ICE) to the mature, ...
gut.bmj7d
Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis
In both compartments, monocyte-derived populations were largely expanded in ... This distinctive gene signature was also found in their bone marrow precursors. The NASH myeloid phenotype was ...