Even outside of the film, they are one. The Substance stars Demi Moore and Margaret Qualley resumed their roles in the body horror film and got into a small "tiff" over whose week it was to be out in the world.

The Substance” co-stars Demi Moore and Margaret Qualley butted heads as they played off their characters in the body horror film in a playfully contentious bit at this year’s Golden Globes on Sunday.

Moore brought a jolt of emotional energy to the room with a speech that touched on her own career in the face of playing an aging actress in 'The Substance.'